Mechanism of Porcine Liver Xanthine Oxidoreductase Mediated N-Oxide Reduction of Cyadox as Revealed by Docking and Mutagenesis Studies

Xanthine oxidoreductase (XOR) is a cytoplasmic molybdenum-containing oxidoreductase, catalyzing both endogenous purines and exogenous compounds. It is suggested that XOR in porcine hepatocytes catalyzes the N-oxide reduction of quinoxaline 1,4-di-N-oxides (QdNOs). To elucidate the molecular mechanis...

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Bibliografiske detaljer
Main Authors: Chen, Chigang, Cheng, Guyue, Hao, Haihong, Dai, Menghong, Wang, Xu, Huang, Lingli, Liu, Zhenli, Yuan, Zonghui
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767608/
https://ncbi.nlm.nih.gov/pubmed/24040113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073912
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