Cooperation between both Wnt/β-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion

Although self-renewal is the central property of stem cells, the underlying mechanism remains inadequately defined. Using a hematopoietic stem and progenitor cell (HSPC)-specific conditional induction line, we generated a compound genetic model bearing both Pten deletion and β-catenin activation. Th...

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Bibliographische Detailangaben
Hauptverfasser: Perry, John M., He, Xi C., Sugimura, Ryohichi, Grindley, Justin C., Haug, Jeffrey S., Ding, Sheng, Li, Linheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2011
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185965/
https://ncbi.nlm.nih.gov/pubmed/21890648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.17421911
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