Stabilisation of p53 enhances reovirus-induced apoptosis and virus spread through p53-dependent NF-κB activation

BACKGROUND: Naturally oncolytic reovirus preferentially kills cancer cells, making it a promising cancer therapeutic. Mutations in tumour suppressor p53 are prevalent in cancers, yet the role of p53 in reovirus oncolysis is relatively unexplored. METHODS: Human cancer cell lines were exposed to Nutl...

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Detalhes bibliográficos
Main Authors: Pan, D, Pan, L-Z, Hill, R, Marcato, P, Shmulevitz, M, Vassilev, L T, Lee, P W K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185941/
https://ncbi.nlm.nih.gov/pubmed/21863032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.325
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