Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria

Mutations in human mitochondrial DNA are often associated with incurable human neuromuscular diseases. Among these mutations, an important number have been identified in tRNA genes, including 29 in the gene MT-TL1 coding for the tRNA(Leu(UUR)). The m.3243A>G mutation was described as the major ca...

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Détails bibliographiques
Auteurs principaux: Karicheva, Olga Z., Kolesnikova, Olga A., Schirtz, Tom, Vysokikh, Mikhail Y., Mager-Heckel, Anne-Marie, Lombès, Anne, Boucheham, Abdeldjalil, Krasheninnikov, Igor A., Martin, Robert P., Entelis, Nina, Tarassov, Ivan
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185436/
https://ncbi.nlm.nih.gov/pubmed/21724600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr546
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