Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome

Mitochondrial mutations, an important cause of incurable human neuromuscular diseases, are mostly heteroplasmic: mutated mitochondrial DNA is present in cells simultaneously with wild-type genomes, the pathogenic threshold being generally >70% of mutant mtDNA. We studied whether heteroplasmy leve...

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Hlavní autoři: Comte, Caroline, Tonin, Yann, Heckel-Mager, Anne-Marie, Boucheham, Abdeldjalil, Smirnov, Alexandre, Auré, Karine, Lombès, Anne, Martin, Robert P., Entelis, Nina, Tarassov, Ivan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592399/
https://ncbi.nlm.nih.gov/pubmed/23087375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks965
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