Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates

A detailed understanding of how aptamers recognize biological binding partners is of considerable importance in the development of oligonucleotide therapeutics. For antiviral nucleic acid aptamers, current models predict a correlation between broad-spectrum inhibition of viral proteins and suppressi...

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Bibliografske podrobnosti
Main Authors: Ditzler, Mark A., Bose, Debojit, Shkriabai, Nikolozi, Marchand, Bruno, Sarafianos, Stefan G., Kvaratskhelia, Mamuka, Burke, Donald H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185408/
https://ncbi.nlm.nih.gov/pubmed/21727088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr381
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