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Reverse Transcriptase in Motion: Conformational Dynamics of Enzyme-Substrate Interactions
Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) catalyzes synthesis of integration-competent, double-stranded DNA from the single-stranded viral RNA genome, combining both polymerizing and hydrolytic functions to synthesize approximately 20,000 phosphodiester bonds. Despite a we...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930377/ https://ncbi.nlm.nih.gov/pubmed/19665597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2009.07.020 |
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