Constitutive Expression of Insulin Receptor Substrate (IRS)-1 Inhibits Myogenic Differentiation through Nuclear Exclusion of Foxo1 in L6 Myoblasts

Insulin-like growth factors (IGFs) are well known to play essential roles in enhancement of myogenic differentiation. In this report we showed that initial IGF-I signal activation but long-term IGF-1 signal termination are required for myogenic differentiation. L6 myoblast stably transfected with my...

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Autors principals: Hakuno, Fumihiko, Yamauchi, Yoko, Kaneko, Gen, Yoneyama, Yosuke, Nakae, Jun, Chida, Kazuhiro, Kadowaki, Tatsuhiko, Yamanouchi, Keitaro, Nishihara, Masugi, Takahashi, Shin-Ichiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185002/
https://ncbi.nlm.nih.gov/pubmed/21991327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025655
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