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Corticostriatal circuit dysfunction in Huntington’s disease: intersection of glutamate, dopamine and calcium
Huntington’s disease (HD) is a noncurable and progressive autosomal-dominant neurodegenerative disorder that results from a polyglutamine expansion in the amino-terminal region of the huntingtin protein. The generation of rodent HD models has revealed that cellular dysfunction, rather than cell deat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3184508/ https://ncbi.nlm.nih.gov/pubmed/21977007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fnl.10.41 |
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