Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain

Binding of erythropoietin (Epo) to the Epo receptor (EpoR) is crucial for production of mature red cells. Although it is well established that the Epo-bound EpoR is a dimer, it is not clear whether, in the absence of ligand, the intact EpoR is a monomer or oligomer. Using antibody-mediated immunoflu...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Constantinescu, Stefan N., Keren, Tzvia, Socolovsky, Merav, Nam, Hyung-song, Henis, Yoav I., Lodish, Harvey F.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31843/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11296286/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081069198
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