Efficient Production of Fah-null Heterozygote Pigs by Chimeric Adeno-Associated Virus-Mediated Gene Knockout and Somatic Cell Nuclear Transfer

Hereditary tyrosinemia type I (HT1) results in hepatic failure, cirrhosis, and hepatocellular carcinoma (HCC) early in childhood and is caused by deficiency in the enzyme fumarylacetoacetate hydrolase (FAH). In a novel approach we used the chimeric adeno-associated virus DJ serotype (AAV-DJ) and hom...

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Hlavní autoři: Hickey, Raymond D., Lillegard, Joseph B., Fisher, James E., McKenzie, Travis J., Hofherr, Sean E., Finegold, Milton J., Nyberg, Scott L., Grompe, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184202/
https://ncbi.nlm.nih.gov/pubmed/21674562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24490
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