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The G-protein coupled bile acid receptor Gpbar1 (TGR5) negatively regulates hepatic inflammatory response through antagonizing Nuclear Factor κB

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response and its mechanism is unkno...

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Bibliografiske detaljer
Main Authors: Wang, Yan-Dong, Chen, Wei-Dong, Yu, Donna, Forman, Barry M., Huang, Wendong
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184183/
https://ncbi.nlm.nih.gov/pubmed/21735468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24525
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