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Axon regeneration pathways identified by systematic genetic screening in C. elegans

The mechanisms underlying the ability of axons to regrow after injury remain poorly explored at the molecular genetic level. We used a laser injury model in Caenorhabditis elegans mechanosensory neurons to screen 654 conserved genes for regulators of axonal regrowth. We uncover several functional cl...

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Autors principals: Chen, Lizhen, Wang, Zhiping, Ghosh-Roy, Anindya, Hubert, Thomas, Yan, Dong, Rourke, Sean O’, Bowerman, Bruce, Wu, Zilu, Jin, Yishi, Chisholm, Andrew D.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183436/
https://ncbi.nlm.nih.gov/pubmed/21943602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.07.009
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