Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction are Associated with Exercise Intolerance in Adults and Adolescents with Homozygous Sickle Cell Anemia in the US and UK

BACKGROUND: Non-invasively assessed pulmonary pressure elevations and left ventricular diastolic dysfunction (LVDD) are associated with increased mortality in adults with sickle cell disease (SCD), but their relationship to exercise intolerance has not been evaluated prospectively. METHODS AND RESUL...

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Detalhes bibliográficos
Main Authors: Sachdev, Vandana, Kato, Gregory J., Gibbs, J. Simon R., Barst, Robyn J., Machado, Roberto F., Nouraie, Mehdi, Hassell, Kathryn L., Little, Jane A., Schraufnagel, Dean E., Krishnamurti, Lakshmanan, Girgis, Reda E., Morris, Claudia R., Rosenzweig, Erika Berman, Badesch, David B., Lanzkron, Sophie, Castro, Oswaldo L., Taylor, James G., Hannoush, Hwaida, Goldsmith, Jonathan C., Gladwin, Mark T., Gordeuk, Victor R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183314/
https://ncbi.nlm.nih.gov/pubmed/21900080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.032920
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