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Reversible Heme-dependent Regulation of Human Cystathionine beta-synthase by a Flavoprotein oxidoreductase()
Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione and contributes to the biogenesis of H(2)S. The presence of a heme cofactor in CBS is enigmatic and its conversion from the ferric to ferrous-CO state inhibits enzyme activity. The low heme redox...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3183264/ https://ncbi.nlm.nih.gov/pubmed/21875066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201270q |
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