Reversible Heme-dependent Regulation of Human Cystathionine beta-synthase by a Flavoprotein oxidoreductase()

Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione and contributes to the biogenesis of H(2)S. The presence of a heme cofactor in CBS is enigmatic and its conversion from the ferric to ferrous-CO state inhibits enzyme activity. The low heme redox...

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Bibliographic Details
Main Authors:	Kabil, Omer, Weeks, Colin L., Carballal, Sebastián, Gherasim, Carmen, Alvarez, Beatriz, Spiro, Thomas G., Banerjee, Ruma
Format:	Artigo
Language:	Inglês
Published:	2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3183264/ https://ncbi.nlm.nih.gov/pubmed/21875066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201270q
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Reversible Heme-dependent Regulation of Human Cystathionine beta-synthase by a Flavoprotein oxidoreductase()

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