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Modulation of the Ribonucleotide Reductase M1 – Gemcitabine Interaction in vivo by N-ethylmaleimide

Ribonucleotide Reductase M1 (RRM1) is the regulatory subunit of the holoenzyme that catalyzes the conversion of ribonucleotides to 2′-deoxyribonucleotides. Its function is indispensible in cell proliferation and DNA repair. It also serves as a biomarker of therapeutic efficacy of the antimetabolite...

詳細記述

保存先:
書誌詳細
主要な著者: Chen, Zhengming, Zhou, Jun, Zhang, Yingtao, Bepler, Gerold
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183154/
https://ncbi.nlm.nih.gov/pubmed/21893046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.08.111
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