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Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an α-Hydroxylation-Dependent Claisen-Like Cyclization Catalyzed by a Dimanganese Thioesterase
The linear tetracyclic TAN-1612 (1) and BMS-192548 (2) were isolated from different filamentous fungal strains, and have been examined as potential neuropeptide Y and neurokinin-1 receptor antagonist respectively. Although the biosynthesis of fungal aromatic polyketides has attracted much interest i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3183131/ https://ncbi.nlm.nih.gov/pubmed/21866960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja206906d |
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