Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD

BACKGROUND: Cigarette smoke, the major risk factor for COPD, is known to activate matrix metalloproteinases in airway epithelium. We investigated whether metalloproteinases, particularly A Disintegrin and Metalloproteinase (ADAM)17, contribute to increased pro-inflammatory epithelial responses with...

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Detalhes bibliográficos
Main Authors: Heijink, Irene H, Brandenburg, Simone M, Noordhoek, Jacobien A, Slebos, Dirk-Jan, Postma, Dirkje S, van Oosterhout, Antoon J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182910/
https://ncbi.nlm.nih.gov/pubmed/21861887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-12-110
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