AAV Mediated GDNF Secretion From Retinal Glia Slows Down Retinal Degeneration in a Rat Model of Retinitis Pigmentosa

Mutations in over 80 identified genes can induce apoptosis in photoreceptors, resulting in blindness with a prevalence of 1 in 3,000 individuals. This broad genetic heterogeneity of disease impacting a wide range of photoreceptor functions renders the design of gene-specific therapies for photorecep...

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Detalhes bibliográficos
Main Authors: Dalkara, Deniz, Kolstad, Kathleen D, Guerin, Karen I, Hoffmann, Natalie V, Visel, Meike, Klimczak, Ryan R, Schaffer, David V, Flannery, John G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182364/
https://ncbi.nlm.nih.gov/pubmed/21522134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.62
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