High resolution hydroxyl radical footprinting of the binding of mithramycin and related antibiotics to DNA.
The preferred binding sites for mithramycin on three different DNA fragments have been determined by hydroxyl radical footprinting. Sequences which appear as one long protected region using DNAase I as a footprinting probe are resolved into several discrete binding domains. Each drug molecule protec...
Guardat en:
| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1989
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| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC318169/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2548163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.14.5447 |
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