Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.

The promoter of the human dihydrofolate reductase (DHFR) gene contains two consensus binding sites for the DNA binding protein Sp1. DNAse protection and gel mobility shift assays demonstrate binding of recombinant Sp1 to both decanucleotide Sp1 binding sequences which are located 49 and 14 base pair...

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Библиографические подробности

Опубликовано в::	J Clin Invest
Главные авторы:	Blume, S W, Snyder, R C, Ray, R, Thomas, S, Koller, C A, Miller, D M
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 1991
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295684/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1834700/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115474
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