Mithramycin blocks protein binding and function of the SV40 early promoter.

Specific interactions between DNA and transcription factors are necessary for transcription initiation. These interactions provide a potential target for the selective inhibition of eukaryotic gene expression. Mithramycin is a DNA binding antibiotic which, in the presence of Mg2+, binds G-C containi...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Ray, R, Snyder, R C, Thomas, S, Koller, C A, Miller, D M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303924/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2542379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114110
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