A Novel Type of Macrothrombocytopenia Associated with a Defect in α2,3-Sialylation

We describe a novel type of human thrombocytopenia characterized by the appearance of giant platelets and variable neutropenia. Searching for the molecular defect, we found that neutrophils had strongly reduced sialyl-Lewis X and increased Lewis X surface expression, pointing to a deficiency in sial...

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Detalhes bibliográficos
Main Authors: Jones, Claire, Denecke, Jonas, Sträter, Ronald, Stölting, Torsten, Schunicht, Yvonne, Zeuschner, Dagmar, Klumperman, Judith, Lefeber, Dirk J., Spelten, Oliver, Zarbock, Alexander, Kelm, Sørge, Strenge, Karen, Haslam, Stuart M., Lühn, Kerstin, Stahl, Dorothea, Gentile, Luca, Schreiter, Thomas, Hilgard, Philip, Beck-Sickinger, Annette G., Marquardt, Thorsten, Wild, Martin K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181377/
https://ncbi.nlm.nih.gov/pubmed/21864493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.012
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