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Catalytic Importance of a Protonated Adenosine in the Hairpin Ribozyme Active Site
The hairpin ribozyme accelerates the rate of phosphodiester transfer reactions by at least 5 orders of magnitude. To achieve this rate enhancement the active site forms via a substrate helix docking event that constrains the scissile phosphate linkage and positions G8 and A38 for catalysis, both of...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3181172/ https://ncbi.nlm.nih.gov/pubmed/20373826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100234v |
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