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The pH Dependence of Hairpin Ribozyme Catalysis Reflects Ionization of an Active Site Adenine
Understanding how self-cleaving ribozymes mediate catalysis is crucial in light of compelling evidence that human and bacterial gene expression can be regulated through RNA self-cleavage. The hairpin ribozyme catalyzes reversible phosphodiester bond cleavage through a mechanism that does not require...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093841/ https://ncbi.nlm.nih.gov/pubmed/21454684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234906 |
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