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Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein
[Image: see text] The technique of hydrogen–deuterium exchange coupled to mass spectrometry (HDX-MS) has been applied to a mesophilic (E. coli) dihydrofolate reductase under conditions that allow direct comparison to a thermophilic (B. stearothermophilus) ortholog, Ec-DHFR and Bs-DHFR, respectively....
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2011
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3180199/ https://ncbi.nlm.nih.gov/pubmed/21859100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200640s |
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