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Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner

Converging evidence from the analysis of human brain tumors and genetically engineered mice has revealed that the mammalian target of rapamycin (mTOR) pathway is a central regulator of glial and glioma cell growth. In this regard, mutational inactivation of neurofibromatosis-1 (NF1), tuberous sclero...

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Hlavní autoři: Banerjee, Sutapa, Crouse, Nikkilina R., Emnett, Ryan J., Gianino, Scott M., Gutmann, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179115/
https://ncbi.nlm.nih.gov/pubmed/21896734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019012108
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