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A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor
Gene clusters found in bacterial species classified as Streptomyces encode the majority of known antibiotics as well as many pharmaceutically active compounds. A site-specific recombination system similar to those that mediate plasmid conjugation was engineered to catalyze tandem amplification of on...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179087/ https://ncbi.nlm.nih.gov/pubmed/21903924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108124108 |
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