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A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor

Gene clusters found in bacterial species classified as Streptomyces encode the majority of known antibiotics as well as many pharmaceutically active compounds. A site-specific recombination system similar to those that mediate plasmid conjugation was engineered to catalyze tandem amplification of on...

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Bibliografski detalji
Glavni autori: Murakami, Takeshi, Burian, Jan, Yanai, Koji, Bibb, Mervyn J., Thompson, Charles J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179087/
https://ncbi.nlm.nih.gov/pubmed/21903924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108124108
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