Solid phase synthesis of oligoribonucleotides using the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) group for the protection of the 2'-hydroxy functions and the H-phosphonate approach.

The solid phase synthesis of oligoribonucleotides using the H-phosphonate approach and the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) and dimethoxytrityl (DMTr) groups, respectively, for the protection of the 2'- and 5'-hydroxy functions is described. The use of a new rea...

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Bibliographic Details
Main Authors: Sakatsume, O, Ohtsuki, M, Takaku, H, Reese, C B
Format: Artigo
Language:Inglês
Published: 1989
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC317850/
https://ncbi.nlm.nih.gov/pubmed/2734100
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