Abnormalities in the Climbing Fiber-Purkinje Cell Circuitry Contribute to Neuronal Dysfunction in ATXN1[82Q] Mice

One fundamental unanswered question in the field of polyglutamine diseases concerns the pathophysiology of neuronal dysfunction. Is there dysfunction in a specific neuronal population or circuit initially that contributes the onset of behavioral abnormalities? This study used a systems-level approac...

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Bibliographic Details
Main Authors: Barnes, Justin A., Ebner, Blake A., Duvick, Lisa A., Gao, Wangcai, Chen, Gang, Orr, Harry T., Ebner, Timothy J.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178465/
https://ncbi.nlm.nih.gov/pubmed/21900557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2579-11.2011
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