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Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases

The pathological processes of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases engender synaptic and neuronal cell damage. While mild oxidative and nitrosative (nitric oxide (NO)-related) stress mediates normal neuronal signaling, excessive accumulation of these fre...

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Detalhes bibliográficos
Main Authors: Nakamura, T, Lipton, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178424/
https://ncbi.nlm.nih.gov/pubmed/21597461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.65
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