Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of K(ATP)-Induced Diabetes

OBJECTIVE: Neonatal diabetes mellitus (NDM) can be caused by gain-of-function ATP-sensitive K(+) (K(ATP)) channel mutations. This realization has led to sulfonylurea therapy replacing insulin injections in many patients. In a murine model of K(ATP)-dependent NDM, hyperglycemia and consequent loss of...

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Autori principali: Remedi, Maria Sara, Agapova, Sophia E., Vyas, Arpita K., Hruz, Paul W., Nichols, Colin G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2011
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178299/
https://ncbi.nlm.nih.gov/pubmed/21813803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0538
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