Cardiac specific ATP-sensitive K+ channel (K(ATP)) overexpression results in embryonic lethality

Transgenic mice overexpressing SUR1 and gain of function Kir6.2[ΔN30, K185Q] K(ATP) channel subunits, under cardiac α-myosin heavy chain (αMHC) promoter control, demonstrate arrhythmia susceptibility and premature death. Pregnant mice, crossed to carry double transgenic progeny, which harbor high le...

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Main Authors: Toib, Amir, Zhang, Hai Xia, Broekelmann, Thomas J., Hyrc, Krzysztof L., Guo, Qiusha, Chen, Feng, Remedi, Maria S., Nichols, Colin G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423334/
https://ncbi.nlm.nih.gov/pubmed/22796573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.07.001
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