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Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance

OBJECTIVE: The molecular mechanisms responsible for pancreatic β-cell dysfunction in type 2 diabetes remain unresolved. Increased expression of the helix-loop-helix protein Id1 has been found in islets of diabetic mice and in vitro models of β-cell dysfunction. Here, we investigated the role of Id1...

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Bibliographic Details
Main Authors: Åkerfeldt, Mia C., Laybutt, D. Ross
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178288/
https://ncbi.nlm.nih.gov/pubmed/21940780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0083
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