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Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet–Induced Glucose Intolerance

Islet β-cells adapt to insulin resistance through increased insulin secretion and expansion. Type 2 diabetes typically occurs when prolonged insulin resistance exceeds the adaptive capacity of β-cells. Our prior screening efforts led to the discovery that adenosine kinase (ADK) inhibitors stimulate...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Navarro, Guadalupe, Abdolazimi, Yassan, Zhao, Zhengshan, Xu, Haixia, Lee, Sooyeon, Armstrong, Neali A., Annes, Justin P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482077/
https://ncbi.nlm.nih.gov/pubmed/28468960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0816
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