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Designed hairpin peptides interfere with amyloidogenesis pathways: Fibril formation and cytotoxicity inhibition, interception of the preamyloid state()
Hairpin peptides bearing cross-strand Trp-Trp and Tyr-Tyr pairs at non-H-bonded strand sites modulate the aggregation of two unrelated amyloidogenic systems: human pancreatic amylin (hAM) and α synuclein (α-syn), associated with type II diabetes and Parkinson’s disease, respectively. In the case of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177973/ https://ncbi.nlm.nih.gov/pubmed/21848289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200760h |
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