AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription

AP-1 proteins heterodimerize via their LZ domains to bind TGACGTCA or TGACTCA, whereas C/EBPs dimerize to bind ATTGCGCAAT. We demonstrate that intact C/EBPα also heterodimerizes with c-Jun or c-Fos to bind a hybrid DNA element, TGACGCAA, or more weakly to TGATGCAA. A 2:1 ratio of c-Jun:C/EBPα or c-F...

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Detalhes bibliográficos
Main Authors: Hong, SunHwa, Skaist, Alyza M., Wheelan, Sarah J., Friedman, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2011
Assuntos:
Spotlight on Leading Edge Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177697/
https://ncbi.nlm.nih.gov/pubmed/21543584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0111043
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