Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers

The transcription factor ΔFosB accumulates in response to chronic insults such as drugs of abuse, L-3,4-dihydroxyphenylalanine (l-DOPA) or stress in specific regions of the brain, triggering long lasting neural and behavioral changes that underlie aspects of drug addiction, dyskinesia, and depressio...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Li, Yi, Liu, Zhiqing, Aglyamova, Galina, Chen, Jianping, Chen, Haiying, Bhandari, Mukund, White, Mark A., Rudenko, Gabrielle, Zhou, Jia
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376976/
https://ncbi.nlm.nih.gov/pubmed/32631520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127300
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