Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

Mutations in leucine-rich repeat kinase 2 (LRRK2) have been identified as a genetic cause of familial Parkinson's disease (PD) and have also been found in the more common sporadic form of PD, thus positioning LRRK2 as important in the pathogenesis of PD. Biochemical studies of the disease-causi...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Zhaohui, Hamamichi, Shusei, Dae Lee, Byoung, Yang, Dejun, Ray, Arpita, Caldwell, Guy A., Caldwell, Kim A., Dawson, Ted M., Smith, Wanli W., Dawson, Valina L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177653/
https://ncbi.nlm.nih.gov/pubmed/21768216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr312
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