Chemical Lead Optimization of a pan G(q) mAChR M(1), M(3), M(5) Positive Allosteric Modulator (PAM) Lead. Part I. Development of the first highly selective M(5) PAM

This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan G(q) mAChR M(1), M(3), M(5) PAM. An iterative library synthesis approach delivered the first select...

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Main Authors: Bridges, Thomas M., Kennedy, J. Phillip, Cho, Hyekyung P., Breininger, Micah L., Gentry, Patrick R., Hopkins, Corey R., Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177601/
https://ncbi.nlm.nih.gov/pubmed/20004578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.089
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