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Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling
The thyroid-stimulating hormone (TSH) receptor signals via G(s) to produce cAMP and via G(q/11) to produce inositol-1,4,5-trisphosphate, which is degraded to inositol monophosphate (IP1; phosphoinositide signaling). The potency of TSH for cAMP signaling is higher than for phosphoinositide signaling,...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Federation of American Societies for Experimental Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177577/ https://ncbi.nlm.nih.gov/pubmed/21705666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-188961 |
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