Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism

Botulinum neurotoxins (BoNTs) deliver a protease to neurons which can cause a flaccid paralysis called botulism. Development of botulism antidotes will require neuronal delivery of agents that inhibit or destroy the BoNT protease. Here, we investigated the potential of engineering Clostridium diffic...

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Bibliographic Details
Main Authors: Krautz-Peterson, Greice, Zhang, Yongrong, Chen, Kevin, Oyler, George A., Feng, Hanping, Shoemaker, Charles B.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177232/
https://ncbi.nlm.nih.gov/pubmed/21941543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/760142
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