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A more efficient method to generate null mutants using Hprt-Cre with floxed alleles
PURPOSE: The generation of non-viable homozygous null mouse embryos from heterozygote null/+ breedings can be highly resource consuming, with only 25% of the embryos in the litter being null mutants. We hypothesized that 1) we could double the number of homozygous null mouse embryos in a litter with...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177085/ https://ncbi.nlm.nih.gov/pubmed/21929979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2011.01.023 |
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