Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

The tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle and provides a paradigm for an emerging class of oligomeric, multidomain proteins with structured and intrinsically disordered regions. Many of its biophysical and functional properties have been extrapolated f...

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Main Authors: Natan, Eviatar, Baloglu, Cetin, Pagel, Kevin, Freund, Stefan M.V., Morgner, Nina, Robinson, Carol V., Fersht, Alan R., Joerger, Andreas C.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176915/
https://ncbi.nlm.nih.gov/pubmed/21457718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.047
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