Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

Lys120 in the DNA-binding domain (DBD) of p53 becomes acetylated in response to DNA damage. But, the role and effects of acetylation are obscure. We prepared p53 specifically acetylated at Lys120, AcK120p53, by in vivo incorporation of acetylated lysine to study biophysical and structural consequenc...

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Библиографические подробности
Главные авторы: Arbely, Eyal, Natan, Eviatar, Brandt, Tobias, Allen, Mark D., Veprintsev, Dmitry B., Robinson, Carol V., Chin, Jason W., Joerger, Andreas C., Fersht, Alan R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100949/
https://ncbi.nlm.nih.gov/pubmed/21525412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105028108
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