Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

Lys120 in the DNA-binding domain (DBD) of p53 becomes acetylated in response to DNA damage. But, the role and effects of acetylation are obscure. We prepared p53 specifically acetylated at Lys120, AcK120p53, by in vivo incorporation of acetylated lysine to study biophysical and structural consequenc...

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Bibliografische gegevens
Hoofdauteurs: Arbely, Eyal, Natan, Eviatar, Brandt, Tobias, Allen, Mark D., Veprintsev, Dmitry B., Robinson, Carol V., Chin, Jason W., Joerger, Andreas C., Fersht, Alan R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100949/
https://ncbi.nlm.nih.gov/pubmed/21525412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105028108
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