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Detection of single DNA base differences by competitive oligonucleotide priming.

Synthetic DNA oligonucleotides can serve as efficient primers for DNA synthesis even when there is a single base mismatch between the primers and the corresponding DNA template. However, when the primer-template annealing is carried out with a mixture of primers and at low stringency the binding of...

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Detalles Bibliográficos
Main Authors: Gibbs, R A, Nguyen, P N, Caskey, C T
Formato: Artigo
Idioma:Inglês
Publicado: 1989
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC317634/
https://ncbi.nlm.nih.gov/pubmed/2717399
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