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Detection of single-base mutation of DNA oligonucleotides with different lengths by terahertz attenuated total reflection microfluidic cell

Many human genetic diseases are caused by single-base mutation in the gene sequence. Since DNA molecules with single-base mutation are extremely difficult to differentiate, existing detection methods are invariably complex and time-consuming. We propose a new label-free and fast terahertz (THz) spec...

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Detalhes bibliográficos
Publicado no:Biomed Opt Express
Main Authors: Tang, Mingjie, Zhang, Mingkun, Xia, Liangping, Yang, Zhongbo, Yan, Shihan, Wang, Huabin, Wei, Dongshan, Du, Chunlei, Cui, Hong-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Optical Society of America 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510857/
https://ncbi.nlm.nih.gov/pubmed/33014620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1364/BOE.400487
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