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Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy
As single agents, ABT-263 and ABT-737 (ABT), molecular antagonists of the Bcl-2 family, bind tightly to Bcl-2, Bcl-xL and Bcl-w, but not to Mcl-1, and induce apoptosis only in limited cell types. The compound 2-deoxyglucose (2DG), in contrast, partially blocks glycolysis, slowing cell growth but rar...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176271/ https://ncbi.nlm.nih.gov/pubmed/21949692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024102 |
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