Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy

As single agents, ABT-263 and ABT-737 (ABT), molecular antagonists of the Bcl-2 family, bind tightly to Bcl-2, Bcl-xL and Bcl-w, but not to Mcl-1, and induce apoptosis only in limited cell types. The compound 2-deoxyglucose (2DG), in contrast, partially blocks glycolysis, slowing cell growth but rar...

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Main Authors: Yamaguchi, Ryuji, Janssen, Edith, Perkins, Guy, Ellisman, Mark, Kitada, Shinichi, Reed, John C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176271/
https://ncbi.nlm.nih.gov/pubmed/21949692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024102
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